AX20017
AX20017 is a small-molecule protein kinase G (PknG) inhibitor (IC50 : 0.39 μM) . It acts by blocking the proliferation of M. tuberculosis. (In Vitro) :The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
Product Specifications
CAS Number
329221-38-7
Purity
>98% (HPLC)
Solubility
DMSO:32 mg/mL (121.06 mM)
Smiles
NC (=O) c1c (NC (=O) C2CC2) sc2CCCCc12
Molecular Formula
C13H16N2O2S
Molecular Weight
264.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (Cyclopropanecarbonylamino) -233a45677a-octahydro-1-benzothiophene-3-carboxamide
Available Sizes
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