Curzerene

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene induces cell apoptosis[1].Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. (In Vitro) :Curzerene (0-100 μM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 μM, and 47.01 μM, respectively.Curzerene (0-100 μM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells.Curzerene (0-100 μM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose.Curzerene (6.25-100 μM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells.Curzerene (6.25-100 μM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells.