MSA-2
MSA-2, a potent and orally available non-nucleotide STING agonist, has EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.
Product Specifications
CAS Number
129425-81-6
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL (169.88 mM; ultrasonic and warming and heat to 80°C)
Smiles
O=C (C1=CC (C (S1) =C2) =CC (OC) =C2OC) CCC (O) =O
Molecular Formula
O=C (C1=CC (C (S1) =C2) =CC (OC) =C2OC) CCC (O) =O
Molecular Weight
294.32
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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