ML349
ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley[2]. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells. (In Vitro) :ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.
Product Specifications
CAS Number
890819-86-0
Purity
>98% (HPLC)
Solubility
DMSO : 20 mg/mL (44.00 mM; Need ultrasonic)
Smiles
COC1=CC=C (N2CCN (C (C3=CC4=C (C (C=CC=C5) =C5S (C4) (=O) =O) S3) =O) CC2) C=C1
Molecular Formula
C??H??N?O?S?
Molecular Weight
454.56
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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