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PF-06446846

PF 06446846 is a potent and selective PCSK9 inhibitor PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing. PF-06446846 is highly selective for the inhibition of PCSK9 translation. The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.

Product Specifications

CAS Number

1632250-49-7

Purity

>98% (HPLC)

Smiles

Clc1cccnc1N ([C@@H]1CCCNC1) C (=O) c1ccc (cc1) -n1nnc2cccnc12

Molecular Formula

C22H20ClN7O

Molecular Weight

433.9

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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