PF-06446846
PF 06446846 is a potent and selective PCSK9 inhibitor PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing. PF-06446846 is highly selective for the inhibition of PCSK9 translation. The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.
Product Specifications
CAS Number
1632250-49-7
Purity
>98% (HPLC)
Smiles
Clc1cccnc1N ([C@@H]1CCCNC1) C (=O) c1ccc (cc1) -n1nnc2cccnc12
Molecular Formula
C22H20ClN7O
Molecular Weight
433.9
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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