SR-717
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity.SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.
Product Specifications
CAS Number
2375421-09-1
Purity
>98% (HPLC)
Solubility
DMSO:14.29 mg/mL (40.69 mM; Need ultrasonic)
Smiles
[Li+].[O-]C (=O) c1cc (F) c (F) cc1NC (=O) c1ccc (nn1) -n1ccnc1
Molecular Formula
C15H8F2LiN5O3
Molecular Weight
351.19
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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