VU 29
VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM) .
Product Specifications
CAS Number
890764-36-0
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (130.08 mM)
Smiles
[O-][N+] (=O) c1ccc (cc1) C (=O) Nc1cc (nn1-c1ccccc1) -c1ccccc1
Molecular Formula
C22H16N4O3
Molecular Weight
384.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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