R-10015
R-10015 is a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket (IC50 of 38 nM for human LIMK1), and a broad-spectrum antiviral compound for HIV infection.R10015 as a lead compound that blocks LIMK activity by binding to the ATP-binding pocket. R10015 specifically blocks viral DNA synthesis, nuclear migration, and virion release. In addition, R10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1), suggesting that LIMK inhibitors could be developed as a new class of broad-spectrum antiviral drugs.
Product Specifications
CAS Number
2097938-51-5
Purity
>98% (HPLC)
Solubility
DMSO:62.5 mg/mL (152.12 mM; Need ultrasonic)
Smiles
COC (=O) c1ccc2[nH]c (nc2c1) C1CCN (CC1) c1ncnc2[nH]cc (Cl) c12
Molecular Formula
C20H19ClN6O2
Molecular Weight
410.86
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Anti-VMAT2/SLC18A2 Antibody Picoband® Fluoro594 Conjugated
MAPK1 (Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, ERT1, Extracellular Signal-regulated Kinase 2, ERK-2, MAP Kinase Isoform p42, p42-MAPK, Mitogen-activated Protein Kinase 2, MAP Kinase 2, MAPK 2, ERK2, PRKM1, PRKM2)