VU591 hydrochloride
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM) . Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 .
Product Specifications
CAS Number
1315380-70-1
Purity
>98% (HPLC)
Solubility
DMSO:16 mg/mL (39.53 mM; Need ultrasonic)
Smiles
Cl.[O-][N+] (=O) c1ccc2nc (COCc3nc4ccc (cc4[nH]3) [N+] ([O-]) =O) [nH]c2c1
Molecular Formula
C16H13ClN6O5
Molecular Weight
404.76
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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