BCH001
BCH001 is a specific small-molecule inhibitor of PAPD5.BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells. When human blood stem cells engineered to carry DC-causing PARN mutations were xenotransplanted into immunodeficient mice, oral treatment with a repurposed PAPD5 inhibitor, the dihydroquinolizinone RG7834, rescued TERC 3' end maturation and telomere length.
Product Specifications
CAS Number
384859-58-9
Purity
>98% (HPLC)
Solubility
DMSO:84 mg/mL (199.84 mM)
Smiles
CCOC (=O) c1cnc2ccc (OC (F) (F) F) cc2c1Nc1ccccc1C (O) =O
Molecular Formula
C20H15F3N2O5
Molecular Weight
420.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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