TY-52156
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM) . TY-52156 displays submicromolar potency and a high degree of selectivity for the S1P3 receptor. TY-52156 inhibits the S1P3 receptor-dependent increase in [Ca2+]i. TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation.After oral administration in vivo, TY-52156 (10 mg/kg, 30 mg/kg; p.o.) inhibits S1P3 receptor-induced bradycardia.
Product Specifications
CAS Number
934369-14-9
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (274.52 mM)
Smiles
CC (C) (C) C (=O) C (\NNc1ccc (Cl) cc1) =N\c1ccc (Cl) cc1
Molecular Formula
C18H19Cl2N3O
Molecular Weight
364.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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