(R) -MG-132
(R) -MG-132 is the enantiomer of MG-132. (R) -MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132. (R) -MG-132 is studied as a potential chymotrypsin-like inhibitor, trypsin-like, and peptidylglutamyl peptide hydrolyzing activities of proteasome. MG-132 and (R) -MG-132 are investigated for inhibition of ChTL, trypsin-like (TL) and peptidylglutamyl peptide hydrolyzing (PGPH) activities of purified 20S proteasomes isolated from human erythrocytes.For (R) -MG-132, the IC50s of 0.22 μM, 34.4 μM, and 2.95 μM for ChTL, TL, and PGPH, respectively. For MG-132, the IC50s of 0.89 μM, 104.43 μM, and 5.7 μM for ChTL, TL, and PGPH, respectively.
Product Specifications
CAS Number
1211877-36-9
Product Name Alternative
(S, R, S) - (-) -MG-132, Z-Leu-D-leu-leu-al
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (210.25 mM)
Smiles
CC (C) C[C@H] (NC (=O) [C@@H] (CC (C) C) NC (=O) [C@H] (CC (C) C) NC (=O) OCc1ccccc1) C=O
Molecular Formula
C26H41N3O5
Molecular Weight
475.62
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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