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MYCi975

MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411, SK-N-B2 cells viability in an MYC-dependent manner (IC50s of 3.7, 3.9, 6.4 μM, respectively) [1].The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability.

Product Specifications

CAS Number

2289691-01-4

Product Name Alternative

NUCC-0200975

Purity

>98% (HPLC)

Solubility

DMSO:247 mg/mL (440.05mM)

Smiles

Cn1nc (cc1-c1ccc (OCc2ccc (Cl) cc2) c (-c2ccc (Cl) c (c2) C (F) (F) F) c1O) C (F) (F) F

Molecular Formula

C25H16Cl2F6N2O2

Molecular Weight

561.3

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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