ICA-27243
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM) . ICA-27243 also has antiepileptic and anticonvulsant effects. ICA-27243 increases both 86Rb+ efflux (EC50 = 0.2 μM) and whole-cell currents in Chinese hamster ovary cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50 = 0.4 μM) . ICA-27243 produces membrane potential hyperpolarization that could be prevented by coadministration with the M-current inhibitors XE-991 and Linopirdine, in SH-SY5Y human neuroblastoma cells .In the mouse maximal electroshock epilepsy model, ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50: 8.4 mg/kg) .
Product Specifications
CAS Number
325457-89-4
Purity
>98% (HPLC)
Solubility
DMSO:247 mg/mL (919.41mM; Need ultrasonic)
Smiles
Fc1ccc (cc1F) C (=O) Nc1ccc (Cl) nc1
Molecular Formula
C12H7ClF2N2O
Molecular Weight
268.65
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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KANK2, ID (KANK2, ANKRD25, KIAA1518, MXRA3, SIP, KN motif and ankyrin repeat domain-containing protein 2, Ankyrin repeat domain-containing protein 25, Matrix-remodeling-associated protein 3, SRC-1-interacting protein) (APC)