LIT-001
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD) .
Product Specifications
CAS Number
2245072-21-1
Purity
>98% (HPLC)
Solubility
DMSO:247 mg/mL (382.53mM; Need ultrasonic)
Smiles
OC (=O) C (F) (F) F.CN (C) C (=S) [C@@H]1CCCN1C (=O) NCc1ccc (cc1C) C (=O) N1Cc2cnn (C) c2Nc2ccccc12
Molecular Formula
C30H34F3N7O4S
Molecular Weight
645.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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