LIT-001
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD) .
Product Specifications
CAS Number
2245072-21-1
Purity
>98% (HPLC)
Solubility
DMSO:247 mg/mL (382.53mM; Need ultrasonic)
Smiles
OC (=O) C (F) (F) F.CN (C) C (=S) [C@@H]1CCCN1C (=O) NCc1ccc (cc1C) C (=O) N1Cc2cnn (C) c2Nc2ccccc12
Molecular Formula
C30H34F3N7O4S
Molecular Weight
645.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
MBP, phosphorylated (Tyr203) (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein) (MaxLight 650) discontinued