Loxoribine
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway. Loxoribine causes maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54, and CCR7. In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells.
Product Specifications
CAS Number
121288-39-9
Product Name Alternative
7-Allyl-8-oxoguanosine, RWJ 21757
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (294.72 mM)
Smiles
Nc1nc2n ([C@@H]3O[C@H] (CO) [C@@H] (O) [C@H]3O) c (=O) n (CC=C) c2c (=O) [nH]1
Molecular Formula
C13H17N5O6
Molecular Weight
339.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Burkholderia xenovorans Thymidylate kinase (tmk)
Recombinant Burkholderia xenovorans Thymidylate kinase (tmk)
Recombinant Burkholderia xenovorans Thymidylate kinase (tmk)
Recombinant Burkholderia xenovorans Thymidylate kinase (tmk)