Loxoribine
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway. Loxoribine causes maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54, and CCR7. In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells.
Product Specifications
CAS Number
121288-39-9
Product Name Alternative
7-Allyl-8-oxoguanosine, RWJ 21757
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (294.72 mM)
Smiles
Nc1nc2n ([C@@H]3O[C@H] (CO) [C@@H] (O) [C@H]3O) c (=O) n (CC=C) c2c (=O) [nH]1
Molecular Formula
C13H17N5O6
Molecular Weight
339.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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