Pentagamavunon-1
Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) . PGV-1 inhibits NF-κB activation[1].
Product Specifications
CAS Number
27060-70-4
Product Name Alternative
PGV-1
UNSPSC
12352005
Target
Apoptosis; COX; NF-κB; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pentagamavunon-1.html
Purity
98.95
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1/C(CC/C1=C\C2=CC(C)=C(O)C(C)=C2)=C/C3=CC(C)=C(O)C(C)=C3
Molecular Formula
C23H24O3
Molecular Weight
348.43
References & Citations
[1]Edy Meiyanto, et al. Curcumin Analog Pentagamavunon-1 (PGV-1) Sensitizes Widr Cells to 5-Fluorouracil Through Inhibition of NF-κB Activation. Asian Pac J Cancer Prev. 2018 Jan 27;19 (1) :49-56.|[2]Beni Lestari, et al. Pentagamavunon-1 (PGV-1) Inhibits ROS Metabolic Enzymes and Suppresses Tumor Cell Growth by Inducing M Phase (Prometaphase) Arrest and Cell Senescence. Sci Rep . 2019 Oct 16;9 (1) :14867.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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