Pentagamavunon-1

Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) . PGV-1 inhibits NF-κB activation[1].

Product Specifications

CAS Number

[27060-70-4]

Product Name Alternative

PGV-1

UNSPSC

12352005

Target

Apoptosis; COX; NF-κB; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pentagamavunon-1.html

Purity

98.95

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1/C(CC/C1=C\C2=CC(C)=C(O)C(C)=C2)=C/C3=CC(C)=C(O)C(C)=C3

Molecular Formula

C23H24O3

Molecular Weight

348.43

References & Citations

[1]Edy Meiyanto, et al. Curcumin Analog Pentagamavunon-1 (PGV-1) Sensitizes Widr Cells to 5-Fluorouracil Through Inhibition of NF-κB Activation. Asian Pac J Cancer Prev. 2018 Jan 27;19 (1) :49-56.|[2]Beni Lestari, et al. Pentagamavunon-1 (PGV-1) Inhibits ROS Metabolic Enzymes and Suppresses Tumor Cell Growth by Inducing M Phase (Prometaphase) Arrest and Cell Senescence. Sci Rep . 2019 Oct 16;9 (1) :14867.