MS154
Product Specifications
UNSPSC Description
MS154 is a first-in-class E3 ligase cereblon-recruiting EGFR degrader with Kds of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutants. MS154 potently inhibits cell proliferation in lung cancer cells[1].
Target Antigen
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms154.html
Solubility
DMSO : 90.14 mg/mL (ultrasonic;warming)
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(NC7=CC=C(C(Cl)=C7)F)N=CN=C6C=C5OC)CC4)=O)=CC=C3)=O)=O
Molecular Weight
901.42
References & Citations
[1]Meng Cheng, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63(3):1216-1232.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141640/MS154-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141640/MS154-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2550393-21-8
Available Sizes
Curated Selection
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