7-O-Methylrosmanol
7-O-Methylrosmanol can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute to its antihyperglycemic activity.In order to find new effective HIV protease inhibitors, two diterpenes (carnosic acid and carnosol) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol and semisynthetic derivatives (7-O-Methylrosmanol, 7-O-ethylrosmanol, and 11,12-O, O-dimethylcarnosol) were prepared. The inhibitory activity of all six compounds against HIV-1 protease was tested. The carnosic acid showed the strongest inhibitory effect (IC90 = 0.08 micrograms/ml) . The same compound was also assayed against HIV-1 virus replication (IC90 = 0.32 micrograms/ml) .
Product Specifications
CAS Number
113085-62-4
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (277.44 mM)
Smiles
[H][C@@]12[C@@H]3OC (=O) [C@@]1 (CCCC2 (C) C) c1c (O) c (O) c (cc1[C@@H]3OC) C (C) C
Molecular Formula
C21H28O5
Molecular Weight
360.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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