GNF351
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR) with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM) . After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.
Product Specifications
CAS Number
1227634-69-6
Purity
>98% (HPLC)
Solubility
DMSO:124 mg/mL (301.34 mM)
Smiles
CC (C) n1cnc2c (NCCc3c[nH]c4ccccc34) nc (nc12) -c1cncc (C) c1
Molecular Formula
C24H25N7
Molecular Weight
411.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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