GPNA hydrochloride
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2 (SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT) . GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.GPNA (10-1000 μM; 48 hours) induces a dose-dependent to reduce of cell viability in A549 cells.
Product Specifications
CAS Number
67953-08-6
Purity
>98% (HPLC)
Solubility
DMSO:124 mg/mL (408.3 mM)
Smiles
Cl.N[C@@H] (CCC (=O) Nc1ccc (cc1) [N+] ([O-]) =O) C (O) =O
Molecular Formula
C11H14ClN3O5
Molecular Weight
303.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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