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O-Desmethyl gefitinib

O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays) . In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.

Product Specifications

CAS Number

847949-49-9

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 100 mg/mL (231.01 mM)

Smiles

Oc1cc2ncnc (Nc3ccc (F) c (Cl) c3) c2cc1OCCCN1CCOCC1

Molecular Formula

C21H22ClFN4O3

Molecular Weight

432.88

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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