O-Desmethyl gefitinib
O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays) . In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.
Product Specifications
CAS Number
847949-49-9
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (231.01 mM)
Smiles
Oc1cc2ncnc (Nc3ccc (F) c (Cl) c3) c2cc1OCCCN1CCOCC1
Molecular Formula
C21H22ClFN4O3
Molecular Weight
432.88
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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