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PKR-IN-C16

PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.

Product Specifications

CAS Number

608512-97-6

Field of Research

Signal Transduction

Purity

>98% (HPLC)

Solubility

DMSO:15.67 mg/mL (58.41 mM)

Smiles

O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1

Molecular Formula

C13H8N4OS

Molecular Weight

268.29

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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