PKR-IN-C16
PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.
Product Specifications
CAS Number
608512-97-6
Field of Research
Signal Transduction
Purity
>98% (HPLC)
Solubility
DMSO:15.67 mg/mL (58.41 mM)
Smiles
O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1
Molecular Formula
C13H8N4OS
Molecular Weight
268.29
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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