Chebulinic acid

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.Chebulinic acid obviously inhibited HQ/Cu (II) - and H (2) O (2) /Cu (II) -mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu (II), the presence of Chebulinic acid inhibited HQ/Cu (II) -mediated double-strand breaks of genomic DNA [1].Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L.