Trans-C75

Trans-C75 ((±) -C75) is an enantiomer of C75. C75 is a synthetic fatty-acid synthase (FASN) inhibitor.

Product Specifications

CAS Number

[191282-48-1]

Product Name Alternative

(±) -C75

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fatty Acid Synthase (FASN)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/C75-trans.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 83.3 mg/mL (ultrasonic; warming)

Smiles

O=C([C@@H](C1=C)[C@@H](CCCCCCCC)OC1=O)O

Molecular Formula

C14H22O4

Molecular Weight

254.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.|[2]Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+) -C75 is a strong anorectic drug; (-) -C75 has antitumor activity. Chirality. 2013 May;25 (5) :281-7.|[3]Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100 (10) :5628-33.|[4]Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99 (14) :9498-502.