Methysticin

Methysticin is a kavalactone isolated from the kava roots. Methylsticin exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neurons and astroglia, decreases peak amplitude of voltage-gated Na+ channels in hippocampal neurons, and suppresses growth of Fusarium, Trichoderma, and Colletotrichum.The kavalactones, and compositions thereof, are useful in mediating osteoclast activity, and as such, are useful in treating or preventing disease or disease symptoms mediated by osteoclast activity.