DBCO-S-S-PEG3-biotin
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label. PEG Linkers can be used in the synthesis of PROTACs.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Product Specifications
CAS Number
1430408-09-5
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
NA
Smiles
O=C (N1C2=CC=CC=C2C#CC3=CC=CC=C3C1) CCC (NCCSSCCC (NCCOCCOCCOCCNC (CCCC[C@H]4[C@] (NC5=O) ([H]) [C@] (N5) ([H]) CS4) =O) =O) =O
Molecular Formula
C42H56N6O8S3
Molecular Weight
869.12
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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