Hoechst 34580
Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.Hoechst 34580 is a good candidate for treating Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.
Product Specifications
CAS Number
23555-00-2
Product Name Alternative
HOE 34580
Purity
>98% (HPLC)
Solubility
DMSO:47 mg/mL (104.08 mM)
Smiles
CN1CCN (C2=CC=C3C (N=C (C4=CC=C5C (N=C (C6=CC=C (N (C) C) C=C6) N5) =C4) N3) =C2) CC1
Molecular Formula
C27H29N7
Molecular Weight
451.57
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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