Pyr6
Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells) .Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca (2+) entry and currents as well as mast cell activation with similar potency. By contrast, Pyr6 exhibited a 37-fold higher potency to inhibit Orai1-mediated Ca (2+) entry as compared with TRPC3-mediated Ca (2+) entry and potently suppressed mast cell activation.
Product Specifications
CAS Number
245747-08-4
Product Name Alternative
N-[4-[3,5-Bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide
Purity
>98% (HPLC)
Solubility
DMSO:95 mg/mL (227.12 mM)
Smiles
O=C (C1=C (F) C=NC=C1) NC2=CC=C (N3N=C (C (F) (F) F) C=C3C (F) (F) F) C=C2
Molecular Formula
C17H9F7N4O
Molecular Weight
418.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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