Brevilin A
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumourIn vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima. The sesquiterpene lactone, Brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM) .
Product Specifications
CAS Number
16503-32-5
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (288.67 mM; Need ultrasonic)
Smiles
C/C=C (C) \C (O[C@H]1[C@@] ([C@@H]2C) ([H]) [C@@] (OC2=O) ([H]) C[C@@H] (C) [C@@]3 ([H]) [C@]1 (C (C=C3) =O) C) =O
Molecular Formula
C20H26O5
Molecular Weight
346.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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