Pralmorelin

Pralmorelin is an oral active synthetic peptide analogue of MEK. Pralmorelin is an auxin releasing peptide/growth hormone secretory receptor agonist, can selectively stimulate ghrelin receptor and cause growth hormone release, has shown anti-inflammatory activity.An anti-inflammatory role for ghrelin (GHRP-2) in PKC-mediated inflammation of granulosa cells, at least in part, due to its inhibitory effect on PKC-induced activation of p38, JNK and NF-κB, possibly by targeting to MKP-1 and PP2A.An insulin tolerance test (ITT), CRH stimulation test, and GHRP-2 test on 47 patients suspected of having a hypothalamo-pituitary disorder were preformed. The results indicate that the GHRP-2 test may induce ACTH secretion from the pituitary gland through direct stimulation.