24-Norursodeoxycholic acid
24-norursodeoxycholic acid is a side chain-shortened C23 homolog of UDCA.It has shown potent anti-inflammatory, anti-cholestatic, and anti-fibrotic properties.It is a Ursodeoxycholic Acid derivative. It is superior to Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice24-norUrsodeoxycholic acid markedly improved liver tests and liver histology and significantly reduced hydroxyproline content and the number of infiltrating neutrophils and proliferating hepatocytes and cholangiocytes. 24-norUrsodeoxycholic acid underwent extensive phase I/II metabolism (hydroxylation, sulfation, and glucuronidation), thereby increasing the hydrophilicity of biliary bile acid secretion. There was a coordinated induction of bile acid detoxifying enzymes (Cyp2b10, Cyp3a11, and Sult2a1) and efflux pumps (Mrp3 and Mrp4) . Ursodeoxycholic acid, in contrast, increased alanine transaminase and alkaline phosphatase levels, had no significant effects on hydroxyproline content, and induced biliary transporters and detoxification enzymes to a much smaller extent than 24-norUrsodeoxycholic acid.
Product Specifications
CAS Number
99697-24-2
Product Name Alternative
Nor-UDCA
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (264.17 mM; Need ultrasonic)
Smiles
C[C@H] (CC (O) =O) [C@H]1CC[C@@]2 ([H]) [C@]3 ([H]) [C@@H] (O) C[C@]4 ([H]) C[C@H] (O) CC[C@]4 (C) [C@@]3 ([H]) CC[C@]12C
Molecular Formula
C23H38O4
Molecular Weight
378.55
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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