SBI-477
SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes. SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4) . Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation.
Product Specifications
CAS Number
781628-99-7
Purity
>98% (HPLC)
Solubility
DMSO:65 mg/mL (134.43 mM; Need ultrasonic)
Smiles
O=C (NC1=NC (C2=CC=C (OC) C=C2) =CS1) C3=CC=C (OCC (N4CCOCC4) =O) C (OC) =C3
Molecular Formula
C24H25N3O6S
Molecular Weight
483.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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