GSK2807 Trifluoroacetate
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM) .GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM) . A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively) .
Product Specifications
CAS Number
2245255-66-5
Purity
>98% (HPLC)
Solubility
H2O:50 mg/mL (88.26 mM)
Smiles
NC1=C2C (N ([C@H]3[C@H] (O) [C@H] (O) [C@@H] (CN (CC[C@H] (N) C (O) =O) CCCN (C) C) O3) C=N2) =NC=N1.OC (C (F) (F) F) =O
Molecular Formula
C21H33F3N8O7
Molecular Weight
566.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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