JTE-013
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively) .JTE-013 is a S1P2 antagonist. JTE-013 (50-200 μM; 1-3 days) decreased cell viability. JTE-013 shows 4.2% inhibition of S1P3 and does not antagonize S1P1 at concentrations up to 10 μM. JTE-013 (10-1000 nM; 30 mins) reverses S1P-induced Akt inhibition and inhibits S1P-induced ERK activation.JTE-013 (gavage; 30 mg/kg daily for 14 consecutive days) decreases tumor size and tumor weight. the modification of JTE-013 to produce the AB1 compound improved potency, intravenous pharmacokinetics, cellular activity, and antitumor activity in NB and may have enhanced clinical and experimental applicability.
Product Specifications
CAS Number
383150-41-2
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (244.92 mM; Need ultrasonic)
Smiles
CC (C1=C2C (N (C) N=C2C) =NC (NNC (NC3=CC (Cl) =NC (Cl) =C3) =O) =C1) C
Molecular Formula
C17H19Cl2N7O
Molecular Weight
408.29
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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