PBIT
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM) . PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively) . PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes . PBIT, which inhibits JARID1B with an IC50 of about 3 μm in vitro. Consistent with this, PBIT treatment inhibited removal of H3K4me3 by JARID1B in cells. Furthermore, this compound inhibited proliferation of cells expressing higher levels of JARID1B.
Product Specifications
CAS Number
2514-30-9
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (414.40 mM; Need ultrasonic)
Smiles
O=C1N (C2=CC=C (C) C=C2) SC3=C1C=CC=C3
Molecular Formula
C14H11NOS
Molecular Weight
241.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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