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PF 6274484

PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.

Product Specifications

CAS Number

1035638-91-5

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 25 mg/mL (67.06 mM)

Smiles

COc (cc (c1c2) ncnc1Nc (cc1) cc (Cl) c1F) c2NC (C=C) =O

Molecular Formula

C18H14ClFN4O2

Molecular Weight

372.8

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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