S1RA (hydrochloride)
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM) . S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization[1][2].
Product Specifications
CAS Number
1265917-14-3
Product Name Alternative
E-52862 hydrochloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/S1RA-hydrochloride.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)
Smiles
CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3.[H]Cl
Molecular Formula
C20H24ClN3O2
Molecular Weight
373.88
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor; Sigma 1 Receptor
Available Sizes
Frequently Asked Questions
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