Lefamulin
Lefamulin is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow. (In Vitro) :Lefamulin (0-1 mg/L) acetate shows inhibitory activity against C. trachomatis, N. gonorrhoeae, and M. genitalium.Lefamulin acetate shows potent activity against all M. pneumoniae strains with MIC values of ≤0.008 μg/mL. (In Vivo) :Lefamulin (10-140 mg/kg, s.c.) acetate shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model.Lefamulin (1.25-160 mg/kg, s.c.) acetate shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice.
Product Specifications
CAS Number
1061337-51-6
Product Name Alternative
BC-3781
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
O=C (O[C@H]1[C@@] ([C@H] (C) CC2) (C) [C@@] (C (CC3) =O) ([H]) [C@]32[C@@H] (C) [C@H] (O) [C@] (C) (C=C) C1) CS[C@H]4[C@H] (O) C[C@H] (N) CC4
Molecular Formula
C28H45NO5S
Molecular Weight
507.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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