NS13001
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels) . The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
Product Specifications
CAS Number
1063331-94-1
Product Name Alternative
N- (4-chlorophenyl) -2- (3,5-dimethylpyrazol-1-yl) -9-methylpurin-6-amine | N- (4-Chlorophenyl) -2- (3,5-dimethyl-1H-pyrazol-1-yl) -9-methyl-9H-purin-6-amine
Purity
>98% (HPLC)
Solubility
DMSO: 90 mg/mL (254.37 mM; Need ultrasonic)
Smiles
Cc1cc (C) nn1-c (nc1Nc (cc2) ccc2Cl) nc2c1ncn2C
Molecular Formula
C17H16ClN7
Molecular Weight
353.81
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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SYNCRIP (Synaptotagmin-binding, Cytoplasmic RNA-interacting Protein, Heterogeneous Nuclear Ribonucleoprotein Q, hnRNP Q, HNRPQ, Glycine- and Tyrosine-rich RNA-binding Protein, GRYRBP, GRY-RBP, NS1-associated Protein 1, NSAP1)
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