Tacrolimus hydrate
Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. It prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro and has strong immunosuppressive activity in vivo.
Product Specifications
CAS Number
109581-93-3
Product Name Alternative
FR 900506 | FR900506 | LCP-Tacro | Prograf | FK 506 | FK-506
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (121.65 mM)
Smiles
O=C ([C@@] (CCCC1) ([H]) N1C (C ([C@@]2 (O) [C@H] (C) C[C@H] (OC) [C@@] (O2) ([H]) [C@@H] (OC) C[C@@H] (C) C/C (C) =C/[C@H]3CC=C) =O) =O) O[C@H] (/C (C) =C/[C@H]4C[C@@H] (OC) [C@H] (O) CC4) [C@H] (C) [C@@H] (O) CC3=O.O
Molecular Formula
C44H71NO13
Molecular Weight
822.05
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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