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Mouse TRAIL Protein

TRAIL

Product Specifications

Background

TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery. Recombinant Mouse TRAIL consisting of the TNF-homologous portion of the extracellular domain of the full length TRAIL protein.

Product Name Alternative

TNF-related apoptosis-inducing ligand, TNFSF10, Apo2 Ligand, TL2, Apo2L, CD253

Gene ID

22035

Accession Number

P50592

Tag

TRAIL

Type

Cytokines and proteins

Applications

No tag

Purity

> 97 % as determined by SDS-PAGE

Activity

Testing in progress

Molecular Formula

20.1 kDa

Molecular Weight

20.1 kDa

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Features & Benefits

Endotoxin : < 0.1 EU per μg of the protein as determined by the LAL method.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage

Protein Length

The recombinant Mouse TRAIL consists of 173 amino acids and predicts a molecular mass of 20.1 kDa.

Formulation

Lyophilized from sterile 20mM Tris, 150mM NaCl, pH 8.0.

Applications Notes

Mouse

Other Product Names

TNF-related apoptosis-inducing ligand, TNFSF10, Apo2 Ligand, TL2, Apo2L, CD253, TNF (TRAIL), Mouse TRAIL Protein

Recommended Usage

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

Preparation

E.coli

Accession Number URL

https://www.uniprot.org/uniprotkb/P50592

AA Sequence

Amino acid sequence derived from Mouse TRAIL (P50592) (Arg119-Asn291) was expressed.

Available Sizes

Frequently Asked Questions

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