Iguratimod
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
Product Specifications
CAS Number
123663-49-0
Product Name Alternative
T614
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/iguratimod.html
Purity
99.93
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1C2=CC(OC3=CC=CC=C3)=C(C=C2OC=C1NC([H])=O)NS(=O)(C)=O
Molecular Formula
C17H14N2O6S
Molecular Weight
374.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Tanaka K, et al. T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts. Jpn J Pharmacol. 1995 Apr;67 (4) :305-14.|[2]Sun Y, et al. Anti-rheumatic drug iguratimod protects against cancer-induced bone pain and bone destruction in a rat model. Oncol Lett. 2017 Jun;13 (6) :4849-4856.|[3]Iguratimod, et al. Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential. J Biol Chem. 2016 Dec 16;291 (51) :26502-26514.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-2
Available Sizes
Frequently Asked Questions
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