SKI-178
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Product Specifications
CAS Number
1259484-97-3
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL (126.77 mM; Need ultrasonic)
Smiles
O=C (C1=CC (C2=CC=C (OC) C=C2) =NN1) N/N=C (C3=CC=C (OC) C (OC) =C3) \C
Molecular Formula
C21H22N4O4
Molecular Weight
394.43
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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