OTS514
OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM) . Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
Product Specifications
CAS Number
1338540-63-8
Product Name Alternative
OTS514 | OTS 514 | OTS-514 | OTS514 Hydrochloride
Purity
>98% (HPLC)
Solubility
DMSO:90 mg/mL (246.94 mM; Need ultrasonic)
Smiles
CC (CN) c (cc1) ccc1-c (c (-c1c2scc1) c (c (C) c1) NC2=O) c1O
Molecular Formula
C21H20N2O2S
Molecular Weight
364.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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